BETA-AMYLOID AS PATHOGENESIS OF ALZHEIMER DISEASE

BETA-AMYLOID AS PATHOGENESIS OF ALZHEIMER DISEASE

Normal 0 false false false EN-US X-NONE X-NONE Alzheimer disease is often causing cognitive decline in elder population.The incidence of this disease is increasing by the age, about 0,3% to 0,6% it affects individuals aged 65 to 69 years, and 5,3% - 7,5% affects individuals aged 65 to 69 years.Alzheimer also affects individuals aged less then 65 ye

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Predictors of switching from nonsteroidal anti-inflammatory drugs to corticosteroids in patients with acute pericarditis and impact on clinical outcome

Background: Aspirin and nonsteroidal anti-inflammatory drugs (A/NSAIDs) are the mainstay treatments for acute pericarditis.We sought to identify factors predicting failure of A/NSAIDs and switch to corticosteroid treatment (STCT) as well as the impact of STCT on pericarditis recurrence.Methods: We enrolled 148 patients with acute pericarditis recei

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Ferroptotic stress promotes the accumulation of pro-inflammatory proximal tubular cells in maladaptive renal repair

Overwhelming lipid peroxidation induces ferroptotic stress and ferroptosis, a non-apoptotic form of regulated cell death that has been implicated in maladaptive renal repair in mice and humans.Using single-cell transcriptomic and mouse genetic approaches, we show that proximal tubular (PT) cells develop a molecularly distinct, pro-inflammatory stat

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Assessment of codivergence of Mastreviruses with their plant hosts

Abstract Background Viruses that have spent most of their evolutionary time associated with a single host lineage should have sequences that reflect codivergence of virus and host.Several examples for RNA viruses of host-virus tree congruence are being challenged.DNA viruses, such as mastreviruses, are more likely than RNA viruses to have maintaine

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